In addition, besides demographics, medication use, blood pressure and laboratory markers for diabetes and renal function testing, we measured the HPSE-1 and hyaluronidase 1 (HYAL-1) activity, and HYAL-4 activity and concentration, together with the endothelial activation markers angiopoietin-2 (ANG2), soluble thrombomodulin (sTM) and MCP-1. The gene discussed is ANGPT2; the disease is diabetes mellitus.