Similarly, Treg cells engineered to express myelin basic protein (MBP)- or myelin oligodendrocyte glycoprotein (MOG)-specific chimeric antigen receptor (CAR)-T cells demonstrated their potential by alleviating symptoms of experimental autoimmune encephalomyelitis (EAE) (mouse model of multiple sclerosis, MS) [42]. The gene discussed is MBP; the disease is experimental autoimmune encephalomyelitis.