MAPT and tauopathy: We focused on Kenyon cells as a group of neurons involved in the behaviorally relevant process of memory and composed of cholinergic neurons, a vulnerable cell type in Drosophila (Wittmann et al. 2001) and human (Whitehouse et al. 1981; Ishida et al. 2015) tauopathies, to define transcriptional programs driving neurodegeneration in response to mutant Tau expression.