CRP and pneumococcal infection: Adjusted CRP response trajectories differed most substantially in Gram-positive infections (Fig. 1A), rising much faster and earlier with Streptococcus pneumoniae infections than other Gram-positive (or Gram-negative) pathogens and peaking at day 1 (mean level ∼290 mg/L), followed by rapid declines and near stability by day 6 (∼65 mg/L).