CRP and infection: Additionally, after adjusting for infection source and pathogen group, CRP levels were independently higher in males (∼20 mg/L higher peak vs. females, Fig. S3A), in episodes with nosocomial onset (20–60 mg/L higher during the episode vs. community-onset, time-interaction p < 0.0001, Fig. S3B) and immunosuppressed patients after day 3 (time-interaction p < 0.0001, Fig. S3C), older patients up to 70 years (∼9 mg/L higher per 10 years older, Fig. S3D) and those with lower Charlson comorbidity scores (Fig. S3E).