Our findings also agree with the report by Krall and colleagues that a similar surgical procedure in mice carrying D2A1 mammary tumors entailed myeloid cell–induced inhibition of cytotoxic lymphocytes with ensuing aggravation of metastasis (27) and extend these earlier findings by implying a role for NOX2-derived ROS as conceivable mediators of surgery-induced immunosuppression. This evidence concerns the gene CYBB and breast cancer.