MD-NGFR–KO mice featured glomerular endothelial injury (based on increased plasmalemmal vesicle associated protein [PLVAP] expression) (26), kidney injury (based on KIM1 expression), and tissue fibrosis (Figure 6, D and E) and showed accumulation of the classic neurodegeneration marker p-tau (S199) in MD cells (Supplemental Figure 6A). Here, PLVAP is linked to Menkes disease.