POLG2 and Familial prostate cancer: Meanwhile, the results of IHC in HPA and tissue array further confirmed that the expression of POLG2 was higher in cancerous tissue compared with normal adjacent tissues (Fig 2A and 2B, Table 1, p = 0.033) and POLG2 expression was related to malignancy of prostate cancer (Table 2, p = 0.038).