MAPT and Mental deterioration: Figs 4 and 5 show that the three most important predictors of RP were plasma Aβ1-42/Aβ1–40 ratio, brain volumetry, and specific cognitive decline areas (e.g., complex attention, learning and memory, language), corroborating the National Institute on Aging- Alzheimer’s Association’s ATN (amyloid, tau, and neurodegeneration) classification [32].