The first reason may be low parameter identifiability and we want to highlight inaccuracies in estimating the pharmacological parameters related to GKr, PCa, and GNaL when the hERG channel was blocked in parallel to the Cav1.2 channel (verapamil) or in parallel to both the Cav1.2 and the Nav1.5-late channel (terfenadine). This evidence concerns the gene SCN5A and posterior cortical atrophy.