INS and type 2 diabetes mellitus: Preclinical studies reported that GSK3B is a negative regulator of Wnt/beta-catenin signaling and bone metabolism (McManus et al., 2005; Chen et al., 2021), and its increase is associated with T2D and alterations in insulin secretion and sensitivity (Nunez Lopez et al., 2022; Xia et al., 2022).