In fact, in this study we also demonstrated that a downregulation of LEF-1 in T2D bone goes along with a downregulation of COL1A1, strengthen data of a reduced production of bone matrix most likely as the result of reduced osteoblasts synthetic activity in diabetes (Manavalan et al., 2012; Khan et al., 2015). This evidence concerns the gene LEF1 and type 2 diabetes mellitus.