LEF-1, a transcription factor that mediates responses to Wnt signal and Wnt target genes itself, and WNT10B, an endogenous regulator of Wnt/beta-catenin signaling and skeletal progenitor cell fate, are both downregulated in bone of postmenopausal women with T2D. The gene discussed is WNT10B; the disease is type 2 diabetes mellitus.