ACTA1 and type 2 diabetes mellitus: Further, co-immunostaining of α-SMA and CD31 (Fig. 8c, d) depicted a higher expression in the dermal layer of both the MSCCxcr2-KLC organoid and MSCGFP-KLC organoid grafted groups indicating enhanced vascularity or endothelialization-mediated skin tissue regeneration in type 2 diabetic wound bed.