Viral amplification in a-IMs was also associated with the induction of five chemokines (CCL2, CCL7, CCL8, CCL13, and CXCL10; Fig. 4 d) and cytokines IL10 and IL6, which is among the molecules central to COVID-19 cytokine storm (Fajgenbaum and June, 2020), as well as TGFB1, the central mediator of fibrogenesis (Fig. 4 e), as well as other genes implicated in profibrotic function (SPP1, GADD45B, ITGB3, and IGFBP4; Table S3). The gene discussed is SPP1; the disease is COVID-19.