Furthermore, populations of polyfunctional allergen-reactive ST2+ Th2 cells producing high levels of IL-9, IL-5, and IL-13, are specifically enriched in allergic individuals who develop asthma and display several features linked to pathogenicity and persistence, which may contribute to asthma pathogenesis (Seumois et al., 2020). The gene discussed is IL1RL1; the disease is asthma.