The improvement of the proinflammatory state represents a huge benefit of periodontaltherapy for patients with obesity, as it interferes with insulin resistance andmetabolic disorders, hepatic steatosis, and cardiovascular diseases.76-84 Subcutaneous and visceral adiposity, CRP, and IL-6 also represent a risk fortype 2 DM.85,86. This evidence concerns the gene CRP and Insulin resistance.