Increased inflammatory factors, disturbances in glycolipid metabolism, and adipokineoverexpression in obesity can be worsened by periodontitis.74 Although serum and GCF concentrations of leptin, adiponectin, and oxidativestress biomarkers remain uncertain and underexplored in the obesity-periodontitisscenario, chemerin, vaspin, omentin-1, and visfatin in GCF improved after NSPT.40,41,45 In the study by Öngöz Dede et al.,42 8-OHdG, a powerful periodontal disease marker,75 significantly decreased in plasma, saliva, and GCF after NSPT. The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.