People with obesity have higher rates of periodontal pathogens and an increased riskof progressive attachment loss than normal-weight individuals.87 Mean Pg, Tf, and Pi counts can be reducedby 7% to 45% 12 weeks after periodontitis therapy88,89 and ranged from 18% to 99% after NSPT in patients with DM.90,91 Periodontal therapy appears to reduce Pg, Pi, Aa, Tf, and Tdcounts for three months,48,49 although Md Tahir et al.49 reported no significant changes in mean Pg andTf counts at 12 weeks of follow-up. The gene discussed is TF; the disease is obesity due to melanocortin 4 receptor deficiency.