The current findings suggest that periodontitis therapy has the potential to improveblood pressure, serum levels of total cholesterol, LDL, triglycerides, HbA1c,insulin resistance, hsCRP, IL-1β, TNF-α and C3, GCF levels of TNF-α, chemerin,vaspin, omentin-1, visfatin and 8-OHdG, and Pg, Pi, Aa, Tf, and Tdcounts. The gene discussed is SERPINA12; the disease is Insulin resistance.