GroEL is an important virulence factor implicated in bacteria-host interaction and may be involved in the progression of periodontitis.P. gingivalis GroEL upregulates inflammatory cytokines (IL-6 and IL-8) in osteoblasts and PDLCs through NF-κB signaling and promotes alveolar bone loss in rats [18,20] . Here, HSPD1 is linked to periodontitis.