This was only found in A*11:01 but not in any other T1D-protective allotypes, which could explain the fact that A*11:01 allotype had the lowest frustration within the T1D-protective allotypes at position 114 and higher than T1D-predisposing HLA-A allotypes at position 116, resulting in less peptide-bound forms and lower surface expression than T1D-predisposing HLA-A allotypes. This evidence concerns the gene HLA-A and type 1 diabetes mellitus.