Polymorphisms within the peptide binding groove were shown to govern the association of HLA-B*27 alleles with ankylosing spondylitis (11), HLA-A*29:02 with Birdshot uveitis, HLA-B*51 with Behçet disease and HLA-C*06:02 with psoriasis (12). The gene discussed is HLA-B; the disease is Behcet disease.