PRAME and acute myeloid leukemia: created PRAMEmTCRCAR-T cells to target the PRAME antigen in AML, and the scFv of CAR-T cells could specifically recognize and bind the ALY/HLA-A2 complex in PRAME+HLA-A2+ AML but not in PRAME-HLA-A2+ or PRAME+HLA-A2- AML (Figure 4).