In this study, we used bioinformatics tools such as single-cell sequencing data analysis and machine learning to identify the key molecular mechanisms associated with DCs in psoriasis, screened FABP5 and KLRB1 as new biomarkers in the diagnosis and treatment process, and investigated drugs with better efficacy in targeting the altered number of DCs, which provided new insights for the clinic. This evidence concerns the gene KLRB1 and psoriasis.