PCK2 and Insulin resistance: longum may also lower the levels of fasting blood glucose as well as alleviate insulin resistance in diabetic mice, enhancing the anti-oxidative capacity, increasing the hepatic glycogen content, decreasing the gene expression levels of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the livers, and thus regulating the disturbance of GM (Hao et al., 2022).