In human genetic studies, a review (60) of genome wide association studies (GWAS) highlighted NELL1 single nucleotide polymorphisms (SNPs) of genome wide significance (P < 5 x 10-8) or suggestive significance (P < 5 x 10-5) in triglyceride metabolism, autism, multiple sclerosis, inflammatory bowel disease (IBD), chronic periodontitis, non-small cell lung cancer (60), as well as in osteoporosis (68, 69). The gene discussed is NELL1; the disease is multiple sclerosis.