BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Of the two cases with concomitant CML and Ph-negative MPN, the interaction between the CALR and BCR::ABL1 clone was available only in 1/2 cases, with the Ph-positive clone sensitive to TKI and the CALR-mutant clone persistent after DMR of CML (Boddu et al., 2018).