LGALS3 and neurodegenerative disease: There have been some reports that galectin-3 of the microglia is important in the CNS, and galectin-3 has recently been the focus of many researchers in the neurodegenerative disease field (Rabinovich, 1999; Rahimian et al., 2018; Tan et al., 2021; Garcia-Revilla et al., 2022).