Specifically, miR-34a-5p directly regulates several target mRNAs encoding proteins related to cell-cycle transition (CCND1, CDK6, Notch1, and Notch2),27,35 apoptosis (Bcl-2 and BIRC5),36,37,38,39 migration, and invasion (Snail and Notch1),40,41,42,43 resulting in the repression of tumor progression. The gene discussed is NOTCH1; the disease is neoplasm.