TRIM25 and colorectal cancer: In colorectal cancer, the oncogenic ubiquitin E3 ligase TRIM25 binds and stabilizes ATAD2 expression following genotoxic stress, which induces a positive ATAD2-E2F-TRIM25 feedback loop whereby ATAD2 acts as a transcriptional co-activator of E2Fs to promote TRIM25 expression.140