SSX2 and cancer: ,196 Furthermore, SSX2 reduces the stability of Polycomb-group (PcG) repressive complexes at the chromosome 1q12 pericentromeric heterochromatin structure, a site of frequent genetic aberrations in cancer, promoting the de-repression of 1q12 heterochromatin and resulting in increased genomic instability due to segregation abnormalities and generation of micronuclei.197