A second set of experiments involved the implantation of GL261-5 murine glioma cells into the brain of C57BL/6 mice, followed by treatment with Delta-24-RGDOX in combination with indoximod in the context of CD4 T cell depletion to decipher their role in the gut microbiota and response to therapy (Figure 1B).24 The gene discussed is CD4; the disease is central nervous system cancer.