CTLA4 and colorectal carcinoma: Furthermore, other studies have shown that in situ tumor ablation combined with locally injected nano-adjuvants (Toll-like receptor agonists PLGA-R837 and poly (lactic-co-glycolic acid)-monophosphoryl lipid A [PLGA-MPLA]) and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) blockade could inhibit metastasis and tumor recurrence in the CRC-PM mice model.90