Several genetic aberrations are associated with GBM onset and closely related to GBM subtypes, such as epidermal growth factor receptor (EGFR) overexpression and gain of Chr.7/loss of Chr.10 (classical GBM subtype), NF1 mutations (mesenchymal GBM subtype) and PDGFRA mutations (proneural GBM subtype) [64–67]. This evidence concerns the gene PDGFRA and glioblastoma.