In addition, Drosophila MTA1-like which is found in our SNCA modifier screen [48], has two human orthologs which are implicated with circadian rhythm-related functions: MTA1, which is an integral component of the circadian transcriptional circuit [268] and MTA3, which is associated with insomnia in a large GWAS meta-analysis [269]. The gene discussed is MTA3; the disease is insomnia.