Furthermore, a negative correlation between serum GH and IGF-I levels was found in the NGRD group in which patients with other pituitary diseases were excluded (exclusion A; R = -0.24, P<0.001; Figure 6A), and the correlation was further enhanced in the NGRD subgroup having BMI less than 22 and albumin levels below 4.0 (R = -0.51, P<0.001; Figure 6B). This evidence concerns the gene ALB and pituitary gland disorder.