SHBG and Stroke: In Fig. 1, genetically predicted SHBG causally increases the stroke risk by 13%, 15%, and 29% decrease in stroke (odds ratio [OR] = 0.87, 95% confidence interval [CI] = 0.79–0.95, P = 0.0041), IS (OR = 0.85, 95%CI = 0.77–0.95, P = 0.0038) and SVS (OR = 0.71, 95%CI = 0.57–0.89, P = 0.0035) risk, respectively.