APOB and coronary artery disorder: Large VLDL particles, rich in triglycerides, may potentially play a role in the development of CHD through mechanisms such as increased formation of highly atherogenic sdLDL50 and increased catabolism of HDL.51,52 Indeed, the reduction of elevated triglyceride levels via agents such as icosapent ethyl has demonstrated efficacy in reducing the risk of cardiovascular events, although this effect may be related to reductions in total apoB-containing particles.53