Recently, Meyer et al. (2024) discovered that the wobbler mouse model of ALS showed hypercorticoidism and neuroinflammation, which could be subsided by treatment with the glucocorticoid receptor (GR) modulator Dazucorilant (CORT113176), indicating that glucocorticoids are probably involved in neuroinflammation. The gene discussed is NR3C1; the disease is amyotrophic lateral sclerosis.