SOD1 and amyotrophic lateral sclerosis: Besides the motor neuron loss, canine models affected by HCSMA share some other pathological features with SOD1-ALS rodent models and patients, such as oligodendrocyte injury, leading to demyelination (Golubczyk et al., 2019), increase in arginase 1-expressing microglia in the proximity of motor neurons (Toedebusch et al., 2018), and upregulation of cannabinoid receptor 2 in reactive astrocytes (Fernández-Trapero et al., 2017).