EGFR and glioblastoma: EGFR Amp was reported to occur in nearly two-thirds of primary GBM, and almost half of those positive for EGFR Amp harbored the mutant EGFRvIII and EGFR single nucleotide variants (SNVs; Brennan et al., 2013; Furnari et al., 2015; Eskilsson et al., 2018; Munoz-Hidalgo et al., 2020).