Previous studies have shown that ACOX1 gene liver-specific knockout reduced hepatic steatosis induced by starvation or a high-fat diet in mice and that the ACOX1-specific inhibitor 10,12-tricosadiynoic acid alleviated hepatic steatosis in rats (Zeng et al., 2017; He et al., 2020b). The gene discussed is ACOX1; the disease is Hepatic steatosis.