Even though downregulation of Slc16a1 and MCT1 protein expression and upregulation of Slc16a3 and MCT4 expression were detected in biopsies of patients with IBD and in the colon of rats or mice with DSS-induced colitis (Thibault et al., 2007; Erdmann et al., 2019; Zhang et al., 2019), our results did not show any effect of DSS on SCFA transporters in SPF mice. Here, SLC16A4 is linked to colitis.