Event: inhibited hypoxia-induced metastasis, angiogenesis, and metabolic reprogramming in hepatocellular carcinoma. mechanism: inhibited the expression of vascular endothelial growth factor, reduces epithelial-mesenchymal transition associated proteins and glycolysis-associated proteins, targets the AMPK/mTOR pathway. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.