In a mouse model of obesity-associated triple-negative breast cancer (E0771 tumor), glucose metabolism was found to be responsive to insulin, and the administration of excessive doses of DAPA and therapeutically relevant doses of CANA impeded cancer progression by attenuating glucose uptake and oxidation in E0771 tumors through the reversal of hyperinsulinemia (Nasiri et al., 2019). Here, INS is linked to neoplasm.