AKT1 and pancreatic neoplasm: In addition, CANA induced early apoptosis of cancer cells and decreased the protein levels of PI3K, p-AKT, p-mTOR, and HIF-1α, indicating that CANA effectively inhibited the growth of pancreatic cancer by inhibiting glycolysis through the PI3K/AKT/mTOR signaling pathway (Xu et al., 2020).