The role of AMPK in inducing G2/M blockade in HCC cells has been demonstrated through its modulation of the transcription factor p53 and the protein p21 (Lee W. et al., 2012; Sanli et al., 2014), as well as the inhibition of hepatic de novo lipogenesis and HCC proliferation via phosphorylation of ACC(Lally et al., 2019). Here, TP53 is linked to hepatocellular carcinoma.