The biological activity of HIF-1 is influenced by the expression of HIF-1α, and the target genes regulated by HIF-1α have been identified to play a role in the systemic physiological responses of HCC to hypoxia, including glycolysis, metastasis, and angiogenesis (Guo et al., 2020). The gene discussed is HIF1A; the disease is hepatocellular carcinoma.