ISSHL group had positive correlations between IgE and CD23, IL10, IL4; IL4 and IL10, CD23+ and CD4+ cells; IL10 and CD23, CD4 (p = 0.000); 25.8% of patients had elevated total IgE levels, and 61.9% had a history of allergy. The gene discussed is IGHE; the disease is allergic disease.