IGHE and Menkes disease: This study found that the mean level of total IgE in serum was significantly higher in MD patients (mean IgE concentration 267.10 ± 394.69 IU/mL) than in the controls (mean IgE concentration 97.78 ± 87.34, p < 0.05) and that there were more subjects in MD group with elevated total IgE (19/46, 41.3%) than in the control group (9/46, 19.5%).