Calciphylaxis is more prevalent in females, predominantly of Caucasian ethnicity.5Multiple risk factors are associated with calciphylaxis, including obesity, diabetes mellitus, immunosuppression, warfarin treatment, hypoalbuminemia, ESRD patients on prolonged dialysis, and hyperparathyroidism.6Dysregulation of calcium, phosphorus, and parathyroid hormone levels results in vascular calcification involving tunica media or intima along with the secondary formation of calcified atherosclerotic plaque in vessel walls. The gene discussed is PTH; the disease is obesity disorder.