It is known that high protein levels of S100A10, S100A11, annexin A2, and/or plasminogen are associated with low survival in breast cancer patients (Supplementary Figure 2D). Finally, we schematized the new machinery as the unique insight shown in Figure 4F: multimerized annexin A2 acts as a plasminogen receptor with the help of S100A11 as well as S100A10, leading to plasmin generation. This evidence concerns the gene ANXA2 and breast cancer.