CEACAM5 and adenoma: For example, a multicenter cohort study evaluating plasma-derived ctDNA methylation haplotype patterns (20-75 base pair fragments and three or more CpG islands) using a 239 marker panel (ColonES Assay) had a sensitivity of 79% (95% CI: 66.5-87.9%) and 86.6% (95% CI: 80.1-90.9%) for detection of advanced adenoma and CRC, respectively, outperforming carcinoembryonic antigen (CEA) and FIT for all CRC stages (42).