Using AR expression to denote luminal-like adenocarcinoma and NE expression to denote stem-like small cell carcinoma, prostate cancer differentiation (from NE+ stem-like to AR+ luminal-like) and dedifferentiation (from AR+ luminal-like to NE+ stem-like) can describe a lineage relationship among the cancer cell types (Figure 8). Here, AR is linked to adenocarcinoma.