HMOX1 and liver dysplastic nodule: However, no significant differences were detected between WT and T1KO mice in the diabetic state (Figure 3) for several genes previously reported in DN pathogenesis, including Bcl-2 (anti-apoptosis gene), inflammation markers (TNF-α, MMP-9, and IL-6), reactive oxygen-related enzymes (Ho-1 and NOX), and inflammasome members (IL-18, IL-1β, and Caspase 1).