Importantly, we also found shared genes between BC genes and hub genes, namely, App in BAT, Vegfa, App in WAT, Lep, Decr1, Cdh1, Cyp2e1, Acadl, Clu, Fgf21, Cfd, Plin5 in muscle, Ugt2b1 in liver, respectively. The gene discussed is APP; the disease is breast cancer.