Several genes, such as MYC, ANXA2, GDF15, AGTR1, NAMPT, LEPR, IGFBP-2, IL1RN, MMP7, and APLNR (9) and JUN, SERPINE1, GINS2, TYMS, HMMR, IGFBP2, BIRC3, TNFRSF12A (10) have been identified as IR signature in non-alcoholic fatty liver disease. The gene discussed is IGFBP2; the disease is metabolic dysfunction-associated steatotic liver disease.