KDR and congestive heart failure: For example, a meta-analysis of 21 trials in different solid tumors that reported data on congestive HF (CHF) showed that subjects in the VEGFR TKI group were at significantly higher risk for CHF than subjects in the non-TKI group (RR = 2.69, p < 0.001, 95% CI: 0.1.86 to 3.87).