Importantly, we have shown that hMT3 is an important driver of the extravasation, cellular migration, and intravasation of HCC cells, and unlike to Huh7mock cells, the metastatic spread of Huh7hMT3 cells is only negligibly inhibited by sorafenib, which is consistent with the regulatory role of MTs in cancer metastasis and resistance previously reported in squamous cell carcinoma of esophagus or colorectal cancers and synchronous liver metastases [57, 58]. This evidence concerns the gene TIMM8A and hepatocellular carcinoma.