TIMM8A and obesity due to melanocortin 4 receptor deficiency: Interestingly, we have also functionally validated that up-regulation of hMT3 in mouse primary hepatocytes resulted in a profound inhibitory effect on the accumulation of intracellular bodies, which is in agreement with the study by Sato and coworkers who demonstrated possible protective effects of MTs against a high-fat diet, lipid accumulation and subsequent development of obesity [78].