Intratumoral T cells activated by mDCs showed a 2.30-fold increase of effector memory T cell (TEM, CD3+CD8+CD44+CD62L−) phenotype, which is capable of triggering strong anti-tumor effect by secreting TNF-α and interferon (IFN)-γ, rather than central memory T cell (TCM, CD3+CD8+CD44+CD62L−) phenotype (Fig. 5C, D) [23]. The gene discussed is TNF; the disease is neoplasm.