AMOTL2 and cancer: Our previous data have shown that the main isoform of AmotL2, p100AmotL2, is exclusively expressed in normal cells, while the shorter isoform, p60AmotL2, has only been observed in cancer cells; the exception being that it is also transiently expressed in non-malignant and redundant cells being extruded by the process of apical extrusion [16].