At each point during the early stage of AKI, MΦ atg5−/− mice did not exhibit any changes in BUN and serum creatinine levels compared with those of the WT littermate mice (Fig. 2A), and the level of kidney inflammation and injury was visualized by the HE staining (Figure S1), indicating that Atg5 deletion in myeloid cells did not affect renal function during early AKI. Here, ATG5 is linked to acute kidney injury.