We attempt to analyze the role of SIRPB1 in the glioma immune microenvironment in detail and determine its activation and related pathways, the release of tumor-promoting cytokines, and its role in prognosis, which provides a basis for further exploration of SIRPB1 as a potential therapeutic target, given the complexity and importance of the glioma immune microenvironment and the incomplete understanding of its mechanism. The gene discussed is SIRPB1; the disease is glioma.