Protein-glutamine gamma-glutamyltransferase 2 (TGM2), which co-immunoprecipitated with MDMX and PICALM (Supplementary Tables 2, 3), catalyzes protein cross-linking, is considered a bridge between inflammation and hypertension, and is upregulated in preeclampsia [35]. This evidence concerns the gene TGM2 and hypertensive disorder.