TRIM21 and autoimmune disease: Although our patients did not show symptoms of autoimmune diseases, a few of the immunoprecipitated proteins listed on Supplementary Table 19 were also among the autoantigens detected by Neiman et al. in healthy adults [52], such as the extensively studied autoantigens TRIM21/Ro(SS-A) and PDC-E2, also an autoantigen in primary biliary cholangitis and other autoimmune diseases.